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Studies demonstrate that postmenopausal women on hormone therapy achieve 30% greater weight loss with semaglutide compared to those not using hormones.[3] The mechanism involves estrogen's ability to increase GLP-1R expression in the brain, particularly during high estrogen phases, and enhance the downstream signaling cascades activated by GLP-1

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Also known as GLP-1 agonists, GLP-1s help regulate blood sugar levels and were originally developed to treat type 2 diabetes

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The researchers were also unable to evaluate the burden that stroke had on each patient because this information was not available in the database