Es importante destacar: * Individualizacin del tratamiento: La decisin sobre la duracin del tratamiento con GLP-1 RA debe ser individualizada y basada en la evaluacin del mdico, considerando los beneficios, los riesgos y las necesidades especficas del paciente
The relationship between timing and side effects is not definitively established in clinical trials, as most studies do not systematically compare morning versus evening administration
A baseline DXA scan before or soon after starting GLP-1 therapy is strongly recommended, especially for post-menopausal women, adults over 50, and anyone with known risk factors for osteoporosis
Wider provision of the drugs through government-sponsored healthcare services, such as Medicare and Medicaid in the US, would be expected to further increase uptake and persistency, especially if prices are materially reduced through negotiated discounts with the pharmaceutical industry
It must be taken on an empty stomach with no more than 120 mL of water, at least 30 minutes before eating, drinking, or taking other medications