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Abbreviations 3-HAA: 3-Hydroxy-anthranilic acid 3-HK: 3-hydroxykynurenine 3xTg-AD: Triple transgenic Alzheimers disease mice 5-HIAA: 5-Hydroxyindoleacetic acid 5-HT: 5-Hydroxytryptamine (serotonin) 5-HTP: 5-Hydroxytryptophan 6-SM: 6-Sulphatoxymelatonin AA: Anthranilic acid AA-5-HT: N-Arachidonoyl-serotonin ACTH: Adrenocorticotropic hormone AD: Alzheimers disease ADHD: Attention-deficit/hyperactivity disorder AhR: Aryl hydrocarbon receptor/receptors ArAT: Aromatic amino acid transaminase ARE: Antioxidant response element AUD: Alcohol use disorder CA1: Cornu Ammonis area 1 CBT: Cognitive-behavioral therapy CBT-I: Cognitive-behavioral therapy for insomnia CMS: Chronic mild stress CNS: Central nervous system COVID-19: Coronavirus disease 2019 CRP: C-reactive protein CRS: Chronic restraint stress CSF: Cerebrospinal fluid CUMS: Chronic unpredictable mild stress ED: Embryonic day EPM: Elevated plus maze FDA: Food and Drug Administration GABA: Gamma-aminobutyric acid GPR35: G protein-coupled receptor 35 HAAO: 3-Hydroxyanthranilate 3,4-dioxygenase HAM-D: Hamilton Depression Rating Scale HCN: Hyperpolarization-activated cyclic nucleotide-gated HIV: Human immunodeficiency virus HO-1: Heme oxygenase-1 HPA: Hypothalamic-pituitary-adrenal IDO: Indoleamine 2,3-dioxygenase IDO1: Indoleamine 2,3-dioxygenase 1 IDO2: Indoleamine 2,3-dioxygenase 2 IFN-: Interferon-gamma IL-10: Interleukin 10 IP: Indole pathway/intraperitoneal ISI: Insomnia Severity Index KAT: Kynurenine aminotransferase KAT II: Kynurenine aminotransferase II KMO: Kynurenine-3-monooxygenase KP: Kynurenine pathway KYN: Kynurenine KYNA: Kynurenic acid KYNU: Kynureninase LAT1: L1 large amino acid transporter LNAAs: Large neutral amino acids MBSR: Mindfulness-based stress reduction MDD: Major depressive disorder MWM: Morris water maze NAD+: Nicotinamide adenine dinucleotide NMDA: N-methyl-D-aspartate Nrf2: Nuclear factor erythroid-derived 2-like 2 NREM: Non-rapid eye movement OFA: Oncin France Souche A PCB2: Procyanidin B-2 PCPA: Parachlorophenylalanine PIC: Picolinic acid PPN: Pedunculopontine nucleus PTSD: Posttraumatic stress disorder QPRT: Quinolinic acid phosphoribosyl transferase QUIN: Quinolinic acid REM: Rapid eye movement ROS: Reactive oxygen species SCN: Suprachiasmatic nuclei of the hypothalamus SD: Sleep deprivation/sleep duration SERT: Serotonin transporter SL: Sleep latency SNRI: Serotonin and norepinephrine reuptake inhibitors SP: Serotonin pathway SRC: Sports-related concussion SSRI: Selective serotonin reuptake inhibitor SSRIs: Selective serotonin reuptake inhibitors SUDs: Substance use disorders SWS: Slow-wave sleep TBI: Traumatic brain injury TDC: Tryptophan decarboxylase TDO: Tryptophan 2,3-dioxygenase TMO: Tryptophan 2-monooxygenase TNA: Tryptophanase TNF-: Tumor necrosis factor- TPH: Tryptophan hydroxylase TRP: Tryptophan TST: Total sleep time WASO: Wake-after-sleep onset ZT: Zeitgeber time References Besedovsky L, Lange T, Haack M (2019) The sleep-immune crosstalk in health and disease