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The significant reasons are IR, obesity, activation of the sympathetic nervous system, and excessive salt consumption (138).IR raises heart rate and blood pressure via upregulating angiotensin II receptors and inhibiting nitric oxide synthesis (139)

Survodutide (BI 456906) is a GLP-1/glucagon co-agonist which has progressed to phase 3 clinical trials as treatment for obesity (SYNCHRONIZE programme)

doi: 10.1038/s41423-022-00902-0 122 HarrisFBerdugoYATreeT

For BPC-157, see What Is BPC-157

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