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Safety Profile The most common adverse events documented across retatrutide results data were gastrointestinal in nature, with incidence increasing at higher doses: Nausea: 6-31% (dose-dependent), primarily during escalation periods Diarrhea: 6-25%, generally mild to moderate Vomiting: 0-16%, occurring mainly in the first weeks of each dose increase Decreased appetite: 3-19%, which contributed to the weight reduction effect Constipation: 3-12%, consistent with GLP-1 receptor-mediated gastric slowing Serious adverse events were rare across all cohorts

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Insulin expression cells were performed on the entire tissue sections by using image analysis software Definiens Developer XD2 (Definiens AG, v.2.7.0)

NALP3-mediated inflammation is a principal cause of progressive renal failure in oxalate nephropathy