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However, a recent meta-analysis of 14 randomized, placebo-controlled trials in 2,149 participants with heart failure found that supplemental coenzyme Q 10 (30-300 mg/day) resulted in a 39% reduction in mortality (seven studies), improved exercise capacity (four studies), but had no effect on left ventricular ejection fraction (nine studies) compared to placebo (34)

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22 Twice daily danuglipron, In a phase 2 study decreased HbA1c by 0.49% to 1.18% in a dose dependent manner, compared to 0.02% for placebo

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