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Nat Rev Neurol 20(4): 245251

However, more participants discontinued treatment with tirzepatide 10 mg (OR 2.39 [95% CI 1.02, 5.59], I 2 0%) and 15 mg (OR 3.64 [95% CI 1.51, 8.78], I 2 13%) when compared with placebo (ESM Table 3)

This enhances the expression of genes involved in mitochondrial function and energy metabolism [84]

PMID 14992380

While TDD systems have demonstrated promising outcomes, scaling up, translating preclinical research into clinical success, and obtaining regulatory approval remain difficulties for commercial success