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Sleep: B12 is involved in regulating melatonin, the hormone that governs your sleep-wake cycle

Dihexa's cognitive research is primarily from a single research program at Washington State University (McCoy et al

Beyond sleep, DSIP has demonstrated a remarkably broad research profile: it modulates the HPA stress axis by reducing basal cortisol and ACTH levels, enhances endogenous opioid signalling to raise pain thresholds without tolerance development, and upregulates antioxidant defence enzymes including SOD, catalase, and glutathione peroxidase

It's a complementary mechanism, not a replacement for established therapies the strongest protocols combine multiple approaches

Truong TTT, Panizzutti B, Kim JH, Walder K