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These should only be used under medical supervision and for brief periods, as they carry their own side effect profiles and safety restrictions

BMJ 313 , 229 (1996)

Contraindications apply

As explained in the Kaiser Family Foundations (KFF) analysis published on November 26, 2025, this $274 figure is the price Medicare will pay to manufacturers, not the patient copay

A smaller number are genuine red flags that need same-day medical attention: acute pancreatitis, gallbladder disease, severe allergic reactions, acute kidney injury from dehydration, NAION (a rare vision disorder), and in people with Type 2 diabetes, hypoglycemia when combined with insulin or a sulfonylurea