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doi: 10.1074/jbc.272.15.10205 139 BlasiusALArnoldCNGeorgelPRutschmannSXiaYLinPet al

All of them are necessary to build and maintain GSH, but some youngsters need more of one than another

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(3) maintenance of mitochondrial homeostasis and downregulation of reactive oxygen species (ROS) generation through activation of peroxisome proliferator-activated receptor coactivator 1 (PGC1), a principal transcriptional coactivator involved in the regulation of mitochondrial biogenesis and function

In addition to the liver and lung issues mentioned, there is also a link between the A1AT PI Z variant and antineutrophil cytoplasmatic antibody (ANCA)- associated vasculitis