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Heme oxygenase 1 (HO-1) is an NRF2 target gene that prevents FH deficiency-mediated succinate stagnation through the heme synthesis and degradation pathway ( BEYOND REGULATING REDOX HOMEOSTASIS: NRF2 PROMOTES ANABOLIC PATHWAYS IN CANCERS In addition to coordinately activating the genes encoding detoxifying enzymes and antioxidant proteins, the constitutive accumulation of Nrf2 confers chemo- and radio-resistance for cancer cell survival

BMC Obes 2:46 Tepaamorndech S, Kirschke CP, Huang L (2014) Linking cellular zinc status to body weight and fat mass: mapping quantitative trait loci in Znt7 knockout mice

Interestingly, other work has investigated the impact of NMN treatment on infertility caused by chemotherapy and radiation treatment, concluding there was no protection from NMN (Stringer et al, 2020)

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