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These effects were not accompanied by reduced locomotor activity or nausea-like behaviour, suggesting that NTS GLP-1R signalling can modulate motivational and reward-related components of feeding rather than merely producing nonspecific malaise (53)

Owing to the extremely efficient enterohepatic circulation of B 12 , the liver can store 3 to 5 years' worth of vitamin B 12

1c,d and Supplementary Fig

Some patients carry genetic variants associated with heightened GLP-1 receptor sensitivity, meaning they experience more pronounced gastrointestinal effects at standard doses