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The improvements we observed are consistent across multiple health systems and patient populations, including groups historically underrepresented in clinical trials. New York Heart Association class, and outflow tract gradients fell by 35-59 mmHg on average, bringing most patients below guideline thresholds for obstruction

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Setting up a laboratory in a prefab on the roof of some old buildings at the back of the Royal Free Hospital in 1960, Samols persuaded Vincent Marks (figure 12), a junior doctor with an interest in carbohydrate metabolism, to help him demonstrate the clinical use of RIA