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[ 14 C]GAA microinjected into rat cerebrum was not effluxed from the brain across the BBB [56], whereas the elimination clearance of GAA via the BCSFB (3.97 L/min per rat) [50] is still approximately 33-fold greater than the apparent blood-to-CSF influx clearance of GAA (0.122 L/min per rat) [56]

Although in their infancy, many exploratory biological biomarkers (Table 2) await translation into clinically relevant tools

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Avoid consuming large amounts of caffeine or alcohol, as they can increase sensitivity and anxiety