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Materials and Methods To date, there is one experimental structure determined by X-ray diffraction of the semaglutide backbone in complex with the extracellular domain (ECD) of GLP-1R (PDB ID: 4ZGM [29]), which is used here as the template for structural modeling by Modeller [44] and ligand-receptor binding affinity (K d ) calculations by Prodigy [45, 46]

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The increase in users with ROS reflects growing trust in the system, while the increase in percentage of automated insulin delivery highlights the system's adaptability

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