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The hub genes were HMOX1, SPP1, CCR2, DCN, IRS1, and IGF1

doi: 10.1038/s41416-020-01156-1 55 SchiliroCFiresteinBL

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In the 50s, when chemotherapy wasnt yet available, massive doses of B12 shots were given to children with a neuroblastoma tumor every two days, for 2-3 years with great success: NEUROBLASTOMA: AN EVALUATION OF ITS NATURAL HISTORY AND EFFECTS OF THERAPY, WITH PARTICULAR REFERENCE TO TREATMENT BY MASSIVE DOSES OF VITAMIN B12

Side effects and safety concerns The combination amplifies risks significantly