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In Se deficiency, GPx activity decreases, degradation of H2O2 is reduced, thyroid cells are less resistant to oxidative stress, apoptosis and cell death occur (9)

Targeting ferroptosis for lung diseases: exploring novel strategies in ferroptosis-associated mechanisms

They can alter the membrane permeability to the antibiotic 139

GPx7 likes to interact with the domain of PDI, and intramolecular cooperation between the two redox-active sites of PDI increases the activity of the Ero1/GPx7/PDI triplet, thereby promoting protein folding mechanisms (Wang et al., 2014) (Figure 6)

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