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Experimental studies have explored potential interactions with multiple signaling systems and regulatory pathways, but no single receptor target has achieved broad consensus

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elegans GST genes showed that knockdown of five, which included one pi ( gst-10 ) and four sigma isoforms ( gst-5 , gst-6 , gst-8 , and gst-24 ), sensitized the worms to exposure to the lipid peroxidation product, 4-hydroxyneoneal (4-HNE) [122]