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While NSAIDs undermine healing by damaging the gut lining and impairing tissue repair, opioids affect pain through a completely different pathway by suppressing pain perception within the central nervous system rather than addressing inflammation or injury

This mechanistic uncertainty limits interpretation of human efficacy data

The second part of this is the fact that within the first couple of days, youre looking at almost half the people are going to get some kind of gastrointestinal side effects, nausea, vomiting, diarrhea, constipation

Clearer Dosing Instructions: To prevent the 2025 surge in dosing errors, new packaging must feature larger text, simplified icons for pen activation, and Quick Start QR codes that lead to video tutorials

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