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Furthermore, clinical manifestations of withdrawal, such as dysphoria and irritability, mirror neurobiological adaptive mechanisms that involve greater stress sensitivity and hyperactivation of the hypothalamic-pituitary-adrenal axis, which could account for the increase in BDNF levels [38, 39]

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Fauser BCJM, Tarlatzis BC, Rebar RW, Legro RS, Balen AH, Lobo R, et al

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Understanding the pharmacological differences helps patients and healthcare providers choose the best option that aligns with their health goals

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