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Hypoglycaemia patients receiving GLP-1 and GIP analogues therapy alongside sulfonylureas or insulin therapy may have an increased risk of adverse effects[511]

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The broad search algorithm combined index terms and free-text words for all GLP-1-RAs, with no restriction to study language, design (including both individual studies and their meta-analyses), setting, comparator and outcome of interest to maximize the comprehensiveness of the evidence synthesis

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However, patients should be aware that whilst preclinical research is promising, many neuroprotective applications remain investigational rather than established clinical practice, with no current MHRA approval for neurological indications

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