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[DOI] [PMC free article] [PubMed] [Google Scholar] 77.Gromada J, Franklin I, Wollheim CB

GLP-1 side effects are typically gastrointestinal (nausea, constipation, diarrhea) and often subside as the body adjusts to the medication

This protective effect was primarily driven by a 30% reduction in liver decompensation events, comprising ascites, hepatic encephalopathy, variceal bleeding, and hepatorenal syndrome (IRR: 0.70, 95%CI: 0.52-0.94, P = 0.020), based on six studies comprising 877,488 participants

These findings are consistent with previous trials with liraglutide at doses up to 2.0 mg in T2DM, 13, 28, 29 and in a phase 2 dose-finding trial in obese individuals without T2DM, 9 about 30% of whom had prediabetes at baseline

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