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Key monitoring parameters include total and free testosterone, SHBG, haematocrit, lipid profile, and liver function at baseline and every 36 months if both treatments are used concurrently

Challenges such as good manufacturing practices (GMP)-compliant production, regulatory standardization, imaging probe pharmacokinetics, and cost-effectiveness must be addressed to ensure clinical integration

Research published in Frontiers in Nutrition in 2025 found that people using GLP-1 medications often consume lower amounts of key nutrients, including vitamin D, calcium, and magnesium, which may affect energy levels and muscle health

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The synergistic role of diet and exercise in the prevention, pathogenesis, and management of ulcerative colitis: an underlying metabolic mechanism