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When comparing POEM plus PPI use to LHM with partial fundoplication, postoperative GERD outcomes are quite comparable

It's contraindicated in patients with a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2

Tretinoin (Retinoic Acid) A gold-standard retinoid that accelerates cellular turnover to improve texture, tone, and visible signs of aging

The majority of side effects are mild-to-moderate and gastrointestinal in nature, occurring most often during dose escalation: Common Side Effects ( 5% of patients) Nausea Vomiting Diarrhoea Constipation Abdominal pain or discomfort Decreased appetite These symptoms typically resolve within the first few weeks as the body adjusts to therapy

Histone modifications The histone modification effect on gene expression mainly includes histones methylation and acetylation