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PLoS One 7(3):e33232

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Detailed PsAID-12 results to 1 year, including responder analyses, have been reported in full elsewhere

DMV Ach neurons directly project to the small intestine and regulate motility Previous studies have shown that the sympathetic system typically inhibits gastrointestinal motility by suppressing smooth muscle contraction and glandular secretion, while the parasympathetic system exerts excitatory regulatory effects 16

For instance, declines in butyrateproducing bacteria ( Faecalibacterium and Akkermansia ) diminish short-chain fatty acid production, thereby weakening PPAR-mediated keratinocyte differentiation and anti-inflammatory effects