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For instance, studies combining metagenomics, metatranscriptomics, and metabolomics in prodromal and established PD have identified early functional alterations in microbial activity, including changes in metabolites such as isovalerate and valerate, and shifts in pathways related to glutamate metabolism, chemotaxis, and flagellar assembly [19]

Currently accepted criteria for bariatric surgery are BMI 35 kg/m 2 , irrespective of metabolic comorbid disease, or BMI between 30 and 35 kg/m 2 and an obesity-related condition (i.e., T2DM, prediabetes, or uncontrolled hypertension) [110]

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Tirzepatide arrived next, demonstrating that dual receptor activation produced superior results

Pharmaceutics 12 , 616 (2020)