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the bloodbrain barrier

in adolescents ages 12 years and above with initial obesity * and body weight above 60 kg ( * obesity (BMI 95th percentile) as defined on sex- and age-specific BMI growth charts (CDC.gov) refer to full datasheet)

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At the pathological mechanism level, animal model experiments have verified direct nephrotoxic effects of metabolites, with relatively substantial evidence in this domain (102, 112)

Standard coagulation tests like PT, APTT, and INR remained unchanged, suggesting the anti-clotting effect works through platelet function rather than the coagulation cascade