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Generally, patients must have a BMI (body mass index) of at least 25 to benefit from this medication

Certainty of evidence At the class-level, certainty of evidence was highest for the GLP-1RA class compared with placebo, with high certainty observed for CV mortality, all-cause mortality, and non-fatal stroke, and moderate certainty for MACE and non-fatal MI, secondary to heterogeneity or imprecision for certain outcomes (Supplementary Table S25)

[1] [3] These combined effects lead to decreased caloric intake and significant weight loss in clinical trials

Emerging research suggests that GLP-1 receptor agonists, the drug class related to tirzepatide's mechanism, may have neuroprotective properties relevant to Parkinson's disease