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Common ferroptosis inducers (FINs) act primarily on the System X c /GSH/GPX4 axis and can be roughly divided into four classes based on their targets: class-1 FINs such as erastin inhibit SLC7A11, class-2 FINs such as RSL3 and ML162 inhibit GPX4 enzyme activity, class-3 FINs such as FIN56 deplete GPX4 and CoQ10, and class-4 FINs induce lipid peroxidation (52)

The pellets were washed once with M9 buffer, transferred to 1.5 mL microcentrifuge tubes, flash-frozen in liquid nitrogen, and stored at 80 C

This research was funded by the Spanish Ministry of Science and Innovation, Interministerial Commission for Science and Technology (CICYT - project RTI2018-095658-B-C33) and Centre for the Development of Industrial Technology (CDTI CIEN program, projects GLOBALVITI and CAVAWINNER).

The topic of skin lightening can be very controversial, but the reality is that there is a large market for skin lightening and learning to treat patients in the safest way is the priority

NAD+ therapy is provided only after medical consultation by a licensed provider