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Results showed that HMSeBA upregulated the protein level of GPX4 in IPEC-J2 cells, while AdshGPX4 significantly decreased the protein abundance of GPX4 compared with control group, under both basal or HMSeBA treatment conditions (Figure 5A)

JAMA Netw Open 2018;1:e180756

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Notably, majority of the preexisting studies evaluated the effect of various antidepressants on BDNF level in patients with depression without pain

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