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Se delivery to neurons by SELENOP is accomplished via its receptor, low-density lipoprotein receptor-related protein 8 (LRP8, also known as ApoER2, Figure 1) ( choroid plexus epithelial cells (Olson et al., 2007, 2008

High methylation of the SLC7A11 promoter suppresses its expression and increases cellular resistance to ferroptosis

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Denaturation is sort of a natural part of life for a protein and is somewhat unavoidable

Lactic acidosis portends a poor prognosis (by Kings College Hospital (KCH) criteria), and the mechanism of lactic acidemia is two-fold: NAPQI being present in excess and causing mitochondrial dysregulation, followed in subsequent hours by tissue hypoxia and decreased hepatic metabolism and clearance of lactate, leading to a two-hit effect on worsening of the lactic acidosis condition