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Melatonin improves oocyte maturation and embryo development while reducing ROS and stabilizing mitochondrial and calcium homeostasis, particularly in IVF patients with DOR or advanced age

By injecting the vitamin directly into the bloodstream, B12 injections achieve maximum absorption, unlike oral supplements

In the intestine, we detected the protein levels of PC1/3 and PKA by Western blot (Figure 4G), and found that the expression of PC1/3 and the phosphorylation level of PKA increased after the treatment of berberine (Figures 4H, I)

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In preclinical models, it increases insulin release and decreases glucagon, which is the activation of GLP-1 receptors