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While human studies on semaglutides effect on obesity-related cognitive function are lacking, it has shown promise in diabetic animals with neurotransmitter receptor dysregulation and brain GLP-1R, improving spatial learning and memory in obese mice and reducing seizure severity [53,57]

Weeks 1-4 Starting dose to assess tolerance Weeks 5-8 First dose increase Weeks 9-12 Therapeutic effects begin Weeks 13-16 Approaching target dose Week 17+ Full maintenance dose Side Effects & Safety Most gastrointestinal side effects are mild, temporary, and occur during the dose escalation period

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By helping patients lose weight, semaglutide can indirectly reduce the mechanical load on the spine and alleviate pain