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457 The organisational and activational effects of testosterone contribute to diabetes development and progression in a mouse model of beta cell endoplasmic reticulum stress L.F

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In addition to a significant reduction in senescent cell burden within tissues treated with FOXO4-DRI, restoration of functional integrity was observed in organs such as the kidneys, liver, and skin

In silico studies predicted that HCQ and other AMDs interacted with cGAS-DNA complex at a site necessary for binding to cGAS and its activation by DNA, and in vitro experiments confirmed that quinacrine blocked the binding between dsDNA and cGAS (78)