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Although DPP-4 inhibitors do not cross the BBB under normal conditions (the pharmacokinetic feature may prevent their repurposing use in neurodegenerative diseases), the permeability of BBB is increased in neurodegenerative diseases, so molecules otherwise unable to cross BBB could enter into CNS in these conditions (103)

This more global therapeutic perspective underpins higher prices and greater access to the market as payers begin to appreciate the economic benefits of early intervention with powerful metabolic drugs and avoiding downstream complications

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