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In circulation, the bioavailability of native IGF-1 is tightly regulated by a family of six IGF binding proteins (IGFBP-1 through IGFBP-6), which sequester ~99% of plasma IGF-1 and limit its receptor-accessible fraction

( in vitro and in vivo studies showed that metformin exerts benefits in several types of cancer

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How do peptides compare with traditional hormone therapies