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Circulating IGFs are synthesized primarily in the liver and exert an endocrine function

In addition to the hot flashes and night sweats typical of women going through menopause, perimenopausal or menopausal women who may also have a growth hormone deficiency may experience: Insomnia Dryness and thinning of the skin and particularly of the vaginal area Weight gain, particularly belly fat Lack of energy Lack of ability to build muscle Weakened immune response Diminished sex drive and loss of sensitivity to stimulation Hair Loss Anxiety Forgetfulness that may include an increase of Alzheimers disease Depression and other mood changes Symptoms also include the potential loss of bone density and increased risk of heart disease

Store at room temperature 68-77F (20-25C)

Funding This work was supported by National Natural Science Foundation of China, China, 81871070