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Women are two to three times as likely as men to have chronic constipation (Jamshed 2011

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GLP1 agonists like Semaglutide, Liraglutide may increase risk of pancreatitis, gastroparesis and bowel obstruction US: Researchers at University of British Columbia have found in a new study that that use of glucagon-like peptide-1 agonists for weight loss compared with use of bupropion-naltrexone was associated with increased risk of pancreatitis, gastroparesis, and bowel obstruction but not biliary disease

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For example, in a 68-week clinical trial, semaglutide users experienced an average weight loss of 15.8%, with 86% of participants achieving clinically meaningful results