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The mechanism-curious optimizer, the engineer who reads pharmacology papers for fun, may end up benefiting most from the biased-signaling story, not because they will take NNC5840 in 2027 but because the molecules that come out of that research program over the next decade are likely to be the ones that get the side-effect profile right for indefinite-duration use in metabolically healthy people

Although 3MST and R196G produced almost the same levels of Cys-SSH and GSSH, 3MST generated greater amounts of Cys-SSSH, Cys-SSSSH, GSSSH and GSSSSH than R196G (Fig

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