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These comparative safety differences make AOD-9604 potentially suitable for individuals who might not tolerate full growth hormone therapy or who have contraindications to traditional GH use

What exists is mechanistic plausibility, preclinical animal data, and observational reports from research settings

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Potential Cost Savings Research demonstrates that viscosupplementation generates significant long-term savings [8]: Individual savings : Delaying surgery by one to two years translates into hundreds to thousands of dollars in avoided out-of-pocket costs, lost wages, and recovery expenses Healthcare system impact : At a population level, modest surgical delays across millions of patients could represent billions of dollars in savings Medication cost reduction : Decreased reliance on NSAIDs, corticosteroids, and opioid medications lowers ongoing medication expenses Why Delaying Surgery Matters Even if knee replacement eventually becomes necessary, postponing it offers advantages: Younger implant age : Prosthetic knees have limited lifespans (15-20 years)

B., Schlienger, J