Generally, very little of a topical product reaches the bloodstream
Illustratively, it is produced in the central nervous system (i.e., brainstems raphe nuclei) (12% of the serotonin in the human body), skin (i.e., Merkel cells), lung (pulmonary neuroendocrine cells), gastrointestinal tract (90% of the serotonin in the human body) (i.e., enterochromaffin cells), and rest of 8% is stored in platelets [166]
Cagrilintide vs retatrutide Retatrutide is a triple agonist targeting GLP-1, GIP, and glucagon receptors simultaneously
Individuals considering use should weigh the strong preclinical cognitive enhancement evidence against the complete absence of controlled human safety data and the theoretical oncogenic concerns
Growth hormone and insulin-like growth factor I treatment increase testicular luteinizing hormone receptors and steroidogenic responsiveness of growth hormone deficient dwarf mice