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Interestingly, higher lactate levels are frequently observed in patients with milder cognitive impairment, indicating a potential compensatory metabolic change or a shift resembling the Warburg effect in the early stages of neurodegeneration

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The upregulation of GSH was opined to be a consequence of Nrf2 signalling activation and increased levels of glutathione metabolising enzymes and their mRNA after exposure to benzo(b)fluoranthene, but not during exposure to phenanthrene (Branco et al., 2021)

They were asked to guess the source of the response and indicate their preferred text