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If this finding proves reproducible, it raises an interesting question: are we looking at improvements secondary to weight loss and better metabolic health, or are we seeing evidence that semaglutide is affecting more fundamental reward-processing mechanisms

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There was no significant difference in concentrations between the treatment groups

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Interestingly, the isolated extracellular domain binds exendin-4 with much higher affinity than the endogenous agonist GLP-1