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Think of it as flipping the switch that tells your body to burn fat as fuel rather than simply reducing the fuel coming in

Hanzel, J

The response of GH secretion to exogenous ghrelin is significantly blunted in obese patients and this response is restored early on after Roux-en-Y gastric bypass (prior to any major weight loss), suggesting that there is an intrinsic resistance to ghrelin in obesity which is reversed with gastric bypass, and which is not linked to weight loss (525)

Developing liver microphysiological systems for biomedical applications