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The modified treatment-regimen estimand represents the estimated average treatment effect regardless of adherence to study intervention or initiation of prohibited weight management treatments, and assuming participants who took rescue orforglipron would not have received any additional improvement from their randomized study treatment

GLP-1R is present on both human monocyte-derived macrophages and the murine macrophage cell line RAW264.7 [86, 87]

Front pharmacol 11:567518 Suwannarach N, Kumla J, Sujarit K, Pattananandecha T, Saenjum C, Lumyong S (2020) Natural bioactive compounds from fungi as potential candidates for protease inhibitors and immunomodulators to apply for coronaviruses

For that reason, research-only context matters

J Clin Oncol 28, 12871293, 10.1200/JCO.2009.25.7246 (2010)