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Thus, therapies targeting mutant p53 may impact the tumor ecosystem by inhibiting protumor signaling, restoring immune surveillance, and reducing tumor heterogeneity

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Ruth Loos, a genetic epidemiologist at the University of Copenhagen, who was not involved in the study, noted that the extra weight loss, on average, may not seem like a lot, but that for those with two copies of the GLP1R variant, it was more than 10 percent of the total weight loss that people experienced in the study population