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Quick Answer: GLP-1 medications quiet food noise by activating receptors in brain regions that regulate appetite and reward processing, reducing neural responses to food cues and diminishing the mental preoccupation with eating

Radiology 207 , 3340 (1998)

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Oral semaglutide also resulted in a greater mean reduction in weight from baseline when compared with liraglutide and placebo (estimated mean change from baseline of -1.6 kg, -1.1 kg, and -0.3 kg, respectively [ P = .0006 for oral semaglutide vs

Weighing risks and benefits of liraglutidethe FDA's review of a new antidiabetic therapy