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In the OASIS 4 trial, the higher 25 mg dose led to about 17 percent average weight loss over 64 weeks when taken as directed, and about one in three patients lost 20 percent or more, broadly similar to the 2.4 mg Wegovy injection
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In contrast, oral semaglutide (the active ingredient in Rybelsus) is exposed to harsh stomach acid and digestive enzymes that break it down before it can be absorbed
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