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Nearly 40% of people with PCOS have trouble getting pregnant naturally, but early research shows that GLP-1 agonists may increase natural pregnancy rates, either on their own or when combined with metformin, more effectively than metformin alone

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Critically, ROS primarily generated at Complexes I and III of the mitochondrial electron transport chain (ETC) directly regulate the HIF signaling pathway [20,21,22,23]