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This complexity is reflected in the many possible ways in which metabolic syndrome might influence high desmoplasia deposition of PDAC, resulting in a dramatic increase in disease aggressiveness, poorer response to treatments, and a decrease in overall patient survival

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Eur J Biochem 263:287293 Cruz F, Scott SR, Barroso I, Santisteban P, Cerdan S (1998) Ontogeny and cellular localization of the pyruvate recycling system in rat brain